@peterimoore looks like some folks from the R world already made a Tufte Hugo theme

This would work out of the box, though you might need/want to add this to the header:

html
<link rel="authorization_endpoint" href="https://micro.blog/indieauth/auth" />
<link rel="token_endpoint" href="https://micro.blog/indieauth/token" />
<link rel="micropub" href="https://micro.blog/micropub" />
<link rel="microsub" href="https://micro.blog/microsub" />
<link rel="webmention" href="https://micro.blog/webmention" />
<link rel="subscribe" href="https://micro.blog/users/follow" />